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Article

Effective antitumor immunity against murine gliomas using dendritic cells transduced with hTERTC27 recombinant adenovirus.

Oncology reports - 1 Apr 2012

Gong Han-Xian, He Lei, Li Xiang-Pen, Wang Yi-Dong, Li Yi, Huang Jun-Jian, Wang Ziling, Xie Dan, Kung Hsiang-Fu, Peng Ying

Abstract excerpt

hTERTC27, a 27-kDa hTERT C-terminal polypeptide has been demonstrated to cause hTERT-positive HeLa cell apoptosis and inhibits the growth of mouse melanoma. hTERTC27 has been associated with telomere dysfunction, regulation of gene-regulated apoptosis, the cell cycle and activation of natural killer (NK) cells, but its mechanism of action is not fully understood. Here, we report that dendritic cells (DCs)...

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Identifiers

PMID: 22210010
DOI: 10.3892/or.2011.1619
PMCID: PMC3583520

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