Article

<i>Tex11</i> Mutant Mouse Models of Human Azoospermia

2026-02-18

Abstract excerpt

Non-obstructive azoospermia (NOA) is the absence of sperm in the ejaculate due to spermatogenic failure. Fifty percent of NOA cases are unexplained but may arise from unidentified genetic mutations. Variants in TEX11 have been identified in men with NOA; and Tex11 knockout in mice causes NOA. Here we attempt to validate three TEX11 variants discovered in NOA patients by knocking them into the orthologous region...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 07618df9-7c67-55de-92d9-f29e5442d4cd
DOI: 10.64898/2026.02.17.706385

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Tex11</i> Mutant Mouse Models of Human AzoospermiaDOI 10.64898/2026.02.17.706385Read

Induced pluripotent stem cell line from a mouse model of human azoospermia with a frameshift mutation Tex11_1260Ins(TT).Semantic proximity Read

Novel mutations of TEX11 are associated with non-obstructive azoospermia.Semantic proximity Read

Identification of deleterious variants in patients with male infertility due to idiopathic non-obstructive azoospermiaSemantic proximity Read

Novel Hemizygous Mutations of TEX11 Cause Meiotic Arrest and Non-obstructive Azoospermia in Chinese Han PopulationSemantic proximity Read

TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse.Semantic proximity Read

Sequencing of a ‘mouse azoospermia’ gene panel in azoospermic men: identification of RNF212 and STAG3 mutations as novel genetic causes of meiotic arrestSemantic proximity Read

Identification of pathogenic mutations from nonobstructive azoospermia patients†.Semantic proximity Read

Diverse Monogenic Subforms of Human Spermatogenic FailureSemantic proximity Read

Disorders of spermatogenesisSemantic proximity Read

Diverse monogenic subforms of human spermatogenic failureSemantic proximity Read

Genetic variants underlying spermatogenic arrests in men with non-obstructive azoospermiaSemantic proximity Read

Two Novel TEX15 Mutations in a Family with Nonobstructive Azoospermia.Semantic proximity Read