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Creation of knock out and knock in mice by CRISPR/Cas9 to validate candidate genes for human male infertility, interest, difficulties and feasibility.

Molecular and cellular endocrinology - 15 Jun 2018

Kherraf Zine-Eddine, Conne Beatrice, Amiri-Yekta Amir, Kent Marie Christou, Coutton Charles, Escoffier Jessica, Nef Serge, Arnoult Christophe, Ray Pierre F

Abstract excerpt

High throughput sequencing (HTS) and CRISPR/Cas9 are two recent technologies that are currently revolutionizing biological and clinical research. Both techniques are complementary as HTS permits to identify new genetic variants and genes involved in various pathologies and CRISPR/Cas9 permits to create animals or cell models to validate the effect of the identified variants, to characterize the pathogeny of the...

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PMID: 29522859
DOI: 10.1016/j.mce.2018.03.002

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PAM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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