Article

Novel Mutations in DNAH14 Cause Male Infertility with Small Head Sperm

2026-05-04

Abstract excerpt

<title>Abstract</title> <p> Purpose To investigate the potential genetic cause in a primary infertility patient with small sperm head. Methods The patient’s sperm was observed by light and electron microscopy. Whole-exome sequencing (WES) was carried out to identify candidate variants. Then the mutations found by WES were verified by Sanger sequencing. DNAH14 protein localization in sperm and the effect of mut...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ca7ec029-8f24-5ac4-9ea1-930e3a18f055
DOI: 10.21203/rs.3.rs-9342351/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel Mutations in DNAH14 Cause Male Infertility with Small Head SpermDOI 10.21203/rs.3.rs-9342351/v1Read

Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility.Semantic proximity Read

Identification of Novel Mutation Sites in DNAH1 of Multiple Morphological Anomalies of the Flagella PatientsSemantic proximity Read

Novel Loss-of-Function Mutations in DNAH1 Displayed Different Phenotypic Spectrum in Humans and Mice.Semantic proximity Read

Novel loss-of-function variants in DNAH17 cause multiple morphological abnormalities of the sperm flagella in humans and mice.Semantic proximity Read

A DNAH17 missense variant causes flagella destabilization and asthenozoospermia.Semantic proximity Read

Mutations in DNAH8 contribute to multiple morphological abnormalities of sperm flagella and male infertility.Semantic proximity Read

Whole-exome sequencing of a cohort of infertile men reveals novel causative genes in teratozoospermia that are chiefly related to sperm head defectsSemantic proximity Read

<i>HIPK4</i> is a novel gene associated with teratozoospermia and male infertilitySemantic proximity Read

Novel compound heterozygous mutations in DNAH1 cause primary infertility in Han Chinese males with multiple morphological abnormalities of the sperm flagella.Semantic proximity Read

Eleven Mutations in Six Genes Causing Abnormal Sperm Morphology: A Case SeriesSemantic proximity Read

Novel Biallelic DNAH1 Variations Cause Multiple Morphological Abnormalities of the Sperm Flagella.Semantic proximity Read

Novel biallelic variants in DNAH1 cause multiple morphological abnormalities of sperm flagella with favorable outcomes of fertility after ICSI in Han Chinese males.Semantic proximity Read