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Article

Embryonic cardiomyocytes can orchestrate various cell protective mechanisms to survive mitochondrial stress.

Journal of molecular and cellular cardiology - 1 Aug 2016

Magarin Manuela, Pohl Toni, Lill Anette, Schulz Herbert, Blaschke Florian, Heuser Arnd, Thierfelder Ludwig, Donath Stefan, Drenckhahn Jörg-Detlef

Abstract excerpt

Whereas adult cardiomyocytes are highly susceptible to stress, cardiomyocytes in the prenatal heart appear to be rather resistant. To investigate how embryonic cardiomyocytes respond to metabolic stress in vivo, we utilized tissue mosaicism for mitochondrial dysfunction in 13.5dpc mouse hearts. The latter is based on inactivation of the X-linked gene encoding Holocytochrome c synthase (Hccs), which is essential...

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Source

Identifiers

PMID: 27106802
DOI: 10.1016/j.yjmcc.2016.04.007

Genes

HCCS
ARC
PRDX3
SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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