Article

Female Alms1-deficient mice develop echocardiographic features of adult but not infantile Alström Syndrome cardiomyopathy

2023-10-19

Abstract excerpt

<h4>Background</h4> Alström Syndrome (AS), a multisystem disorder caused by biallelic ALMS1 mutations, features major cardiac complications often causing early mortality. These are biphasic, including infantile dilated cardiomyopathy, and distinct adult-onset cardiomyopathy. Cardiomyocyte maturation defects, cardiac fibrosis and early atherosclerosis have all been invoked as contributors to heart failure in AS,...

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Literature Corpus work: da6c4c2e-4c5d-58ca-bf62-569470392e52
DOI: 10.1101/2023.10.16.562570

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