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Article

The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size.

Journal of molecular and cellular cardiology - 1 Aug 2016

Christensen Alex Hørby, Chatelain Franck C, Huttner Inken G, Olesen Morten Salling, Soka Magdalena, Feliciangeli Sylvain, Horvat Claire, Santiago Celine F, Vandenberg Jamie I, Schmitt Nicole, Olesen Søren-Peter, Lesage Florian, Fatkin Diane

Abstract excerpt

The two-pore domain potassium (K(+)) channel TWIK-1 (or K2P1.1) contributes to background K(+) conductance in diverse cell types. TWIK-1, encoded by the KCNK1 gene, is present in the human heart with robust expression in the atria, however its physiological significance is unknown. To evaluate the cardiac effects of TWIK-1 deficiency, we studied zebrafish embryos after knockdown of the two KCNK1 orthologues,...

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Source

Identifiers

PMID: 27103460
DOI: 10.1016/j.yjmcc.2016.04.006

Genes

KCNK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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