Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation of the Na+/K+-ATPase Atp1a1a.1 causes QT interval prolongation and bradycardia in zebrafish.

Journal of molecular and cellular cardiology - 1 Jul 2018

Pott Alexander, Bock Sarah, Berger Ina M, Frese Karen, Dahme Tillman, Keßler Mirjam, Rinné Susanne, Decher Niels, Just Steffen, Rottbauer Wolfgang

Abstract excerpt

The genetic underpinnings that orchestrate the vertebrate heart rate are not fully understood yet, but of high clinical importance, since diseases of cardiac impulse formation and propagation are common and severe human arrhythmias. To identify novel regulators of the vertebrate heart rate, we deciphered the pathogenesis of the bradycardia in the homozygous zebrafish mutant hiphop (hip) and identified a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Action Potentials
Share to Atrioventricular Block

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bradycardia

Share to Electric Stimulation

Share to Genes, Modifier

Share to Heart Rate

Share to Ion Transport

Share to Sodium-Potassium-Exchanging ATPase

Source

Identifiers

PMID: 29750993
DOI: 10.1016/j.yjmcc.2018.05.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation of the Na+/K+-ATPase Atp1a1a.1 causes QT interval prolongation and bradycardia in zebrafish.PMID 29750993Read ↗

Zebrafish: a novel research tool for cardiac (patho)electrophysiology and ion channel disordersSemantic proximity Read ↗

A transgenic zebrafish model of a human cardiac sodium channel mutation exhibits bradycardia, conduction-system abnormalities and early death.Semantic proximity Read ↗

Mutant KCNJ3 and KCNJ5 Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial FibrillationSemantic proximity Read ↗

Zebrafish as a model for long QT syndrome: the evidence and the means of manipulating zebrafish gene expressionSemantic proximity Read ↗

Functional Genomics in Zebrafish as a Tool to Identify Novel Antiarrhythmic TargetsSemantic proximity Read ↗

A Novel Art of Electrocardiogram Assessment in Zebrafish for Cardiovascular Disease Studies and Drug ScreeningSemantic proximity Read ↗

Modeling Human Cardiac Arrhythmias: Insights from ZebrafishSemantic proximity Read ↗

The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size.Semantic proximity Read ↗

Zebrafish heart as a model for human cardiac electrophysiologySemantic proximity Read ↗

Na,K-ATPase is essential for embryonic heart development in the zebrafish.Semantic proximity Read ↗

Adult and Developing Zebrafish as Suitable Models for Cardiac Electrophysiology and Pathology in Research and IndustrySemantic proximity Read ↗

Kir 2.1 channelopathies: the Andersen-Tawil syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.