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Article

Isolation of Pancreatic Cancer Cells from a Patient-Derived Xenograft Model Allows for Practical Expansion and Preserved Heterogeneity in Culture.

The American journal of pathology - 1 Jun 2016

Pham Kien, Delitto Daniel, Knowlton Andrea E, Hartlage Emily R, Madhavan Ricky, Gonzalo David H, Thomas Ryan M, Behrns Kevin E, George Thomas J, Hughes Steven J, Wallet Shannon M, Liu Chen, Trevino Jose G

Abstract excerpt

Commercially available, highly passaged pancreatic cancer (PC) cell lines are of limited translational value. Attempts to overcome this limitation have primarily consisted of cancer cell isolation and culture directly from human PC specimens. However, these techniques are associated with exceedingly low success rates. Here, we demonstrate a highly reproducible culture of primary PC cell lines (PPCLs) from...

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Identifiers

PMID: 27102771
DOI: 10.1016/j.ajpath.2016.02.009
PMCID: PMC4901138

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