Expression of <i>ANRIL</i> –Polycomb Complexes– <i>CDKN2A/B/ARF</i> Genes in Breast Tumors: Identification of a Two-Gene ( <i>EZH2/CBX7</i> ) Signature with Independent Prognostic Value

Abstract excerpt

UNLABELLED: ANRIL, a long noncoding RNA (lncRNA), has recently been reported to have a direct role in recruiting polycomb repressive complexes PRC2 and PRC1 to regulate the expression of the p15/CDKN2B-p16/CDKN2A-p14/ARF gene cluster. Expression analysis of ANRIL, EZH2, SUZ12, EED, JARID2, CBX7, BMI1, p16, p15, and p14/ARF genes was evaluated in a large cohort of invasive breast carcinomas (IBC, n = 456) by...

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