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Article

Gene expression profiling of Polycomb, Hox and Meis genes in patients with acute myeloid leukaemia

10 Apr 2008

Abstract excerpt

The Polycomb group (PcG) of genes is important for differentiation and cell-cycle regulation and is aberrantly expressed in several cancers. To analyse the role of deregulated PcG genes in acute myeloid leukaemia (AML), we determined by RQ-PCR the expression of the PcG genes BMI-1, MEL18, SCML2, YY1 and EZH2, and the downstream PcG targets HOXA4, HOXA9 and MEIS1 in diagnostic bone marrow samples from 126 AML...

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PMID: 18410541
DOI: 10.1111/j.1600-0609.2008.01083.x

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