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Article

Cell autonomous and microenvironmental regulation of tumor progression in precursor states of multiple myeloma.

Current opinion in hematology - 1 Jul 2016

Manier Salomon, Kawano Yawara, Bianchi Giada, Roccaro Aldo M, Ghobrial Irene M

Abstract excerpt

PURPOSE OF REVIEW: Multiple myeloma is a plasma cell malignancy evolving in the bone marrow and leading to end organ damage such as bone lesions, cytopenias, and kidney failure. This review delineates recent advances in the molecular mechanisms leading to tumor progression in multiple myeloma. Two different aspects enable tumor expansion: cell autonomous through genomic alterations in the tumor clone and noncell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27101529
DOI: 10.1097/MOH.0000000000000259

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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