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Pathogenesis of Myeloma

24 Jan 2011

Abstract excerpt

Multiple myeloma (MM) is a neoplasm of post-germinal center, terminally differentiated B cells. It is characterized by a multifocal proliferation of clonal, long-lived plasma cells within the bone marrow (BM) and associated skeletal destruction, serum monoclonal gammopathy, immune suppression, and end-organ sequelae. MM is preceded by an age-progressive premalignant condition termed monoclonal gammopathy of...

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PMID: 21261519
DOI: 10.1146/annurev-pathol-011110-130249

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