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Article

Gab2 promotes hematopoietic stem cell maintenance and self-renewal synergistically with STAT5.

PloS one - 10 Feb 2010

Li Geqiang, Wang Zhengqi, Miskimen Kristy L, Zhang Yi, Tse William, Bunting Kevin D

Abstract excerpt

BACKGROUND: Grb2-associated binding (Gab) adapter proteins play major roles in coordinating signaling downstream of hematopoietic cytokine receptors. In hematopoietic cells, Gab2 can modulate phosphatidylinositol-3 kinase and mitogen associated protein kinase activities and regulate the long-term...

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Identifiers

PMID: 20161778
DOI: 10.1371/journal.pone.0009152
PMCID: PMC2818849

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20161778-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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