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Article

Prevalence of HIV-1 drug resistance mutations in proviral DNA in the Swiss HIV Cohort Study, a retrospective study from 1995 to 2018.

The Journal of antimicrobial chemotherapy - 5 Sept 2023

Jaha Bashkim, Schenkel Corinne D, Jörimann Lisa, Huber Michael, Zaheri Maryam, Neumann Kathrin, Leemann Christine, Calmy Alexandra, Cavassini Matthias, Kouyos Roger D, Günthard Huldrych F, Metzner Karin J

Abstract excerpt

BACKGROUND: Genotypic resistance testing (GRT) is routinely performed upon diagnosis of HIV-1 infection or during virological failure using plasma viral RNA. An alternative source for GRT could be cellular HIV-1 DNA. OBJECTIVES: A substantial number of participants in the Swiss HIV Cohort Study (SHCS) never received GRT. We applied a method that enables access to the near full-length proviral HIV-1 genome without...

Topics

Drug Resistance, Viral
HIV-1
DNA
Mutation
Switzerland
HIV Infections
Retrospective Studies
Humans
Male
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Adult

Middle Aged

DNA-Directed DNA Polymerase

Prevalence

Source

Open in PubMed Open full text

Identifiers

PMID: 37545164
DOI: 10.1093/jac/dkad240
PMCID: PMC10477134

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-37545164-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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