Article
HIV-1 genotyping of the protease-reverse transcriptase and integrase genes to detect mutations that confer antiretroviral resistance.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013
Van den Eede Peter, Van Wesenbeeck Liesbeth, Verlinden Yvan, Feyaerts Maxim, Smits Veerle, Verheyen Ann, Vanhooren Leen, Deloof Alain, Villacian Jorge, Pattery Theresa
Abstract excerpt
Major advances in antiretroviral (ARV) therapy during the last decade have made HIV-1 infections a chronic, manageable disease. In spite of these significant advancements, ARV drug resistance remains a hurdle for HIV-infected patients who are committed to lifelong treatments. Several commercially marketed and/or laboratory-developed tests (LDT) are available to detect resistance-associated mutations (RAMs) in...
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