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DNA methylation and targeted sequencing of methyltransferases family genes in canine acute myeloid leukaemia, modelling human myeloid leukaemia.

Veterinary and comparative oncology - 1 Sept 2017

Bronzini I, Aresu L, Paganin M, Marchioretto L, Comazzi S, Cian F, Riondato F, Marconato L, Martini V, Te Kronnie G

Abstract excerpt

Tumours shows aberrant DNA methylation patterns, being hypermethylated or hypomethylated compared with normal tissues. In human acute myeloid leukaemia (hAML) mutations in DNA methyltransferase (DNMT3A) are associated to a more aggressive tumour behaviour. As AML is lethal in dogs, we defined global DNA methylation content, and screened the C-terminal domain of DNMT3 family of genes for sequence variants in 39...

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PMID: 27098563
DOI: 10.1111/vco.12231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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