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Effect of 24 cytochrome P450 2D6 variants found in the Chinese population on the N-demethylation of amitriptyline in vitro.

Pharmaceutical biology - 1 Nov 2016

Weng Qinghua, Liang Bingqing, Zhou Yali, Li Xiangyu, Wang Hao, Zhan Yunyun, Dai Dapeng, Cai JianPing, Hu Guoxin

Abstract excerpt

CONTEXT: Amitriptyline (AT), one of the tricyclic antidepressants, is still widely used for the treatment of the depression and control of anxiety states and panic disorders in the developing countries. OBJECTIVE: This study evaluates the catalytic activities of CYP2D6*1, CYP2D6*2, CYP2D6*10 and 22 novel alleles in Han Chinese population and their effects on the N-demethylation of AT in vitro. MATERIALS AND...

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Identifiers

PMID: 27097346
DOI: 10.3109/13880209.2016.1160250

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