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Article

The role of CYP2C19 in amitriptyline N-demethylation in Chinese subjects.

European journal of clinical pharmacology - 1 May 2002

Jiang Zhi-Ping, Shu Yan, Chen Xiao-Ping, Huang Song-Lin, Zhu Rong-Hua, Wang Wei, He Nan, Zhou Hong-Hao

Abstract excerpt

OBJECTIVE: To determine the role of cytochrome P(450) (CYP)2C19 in N-demethylation of amitriptyline (AT) in healthy Chinese subjects. METHODS: One hundred and one subjects were genotyped for CYP2C19 using polymerase chain reaction-restriction fragment length polymorphism analysis. Twelve unrelated adult men (19.7+/-0.6 years, 61.8+/-3.8 kg) were chosen and orally given a single dose of 50 mg AT, and the blood...

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Identifiers

PMID: 12012142
DOI: 10.1007/s00228-002-0445-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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