Article
A Study on CYP2C19 and CYP2D6 Polymorphic Effects on Pharmacokinetics and Pharmacodynamics of Amitriptyline in Healthy Koreans.
Clinical and translational science - 1 Mar 2017
Ryu S, Park S, Lee J H, Kim Y R, Na H S, Lim H S, Choi H Y, Hwang I Y, Lee J G, Park Z W, Oh W Y, Kim J M, Choi S E
Abstract excerpt
We performed a double-blinded, genotype-based stratification study to explore the pharmacokinetics and pharmacodynamics of amitriptyline according to CYP2C19 and CYP2D6 genotype in Korean subjects. Twenty-four healthy adults were grouped by genotype of CYP2C19 and CYP2D6. After a single dose of 25 mg of amitriptyline, blood samples were collected and anticholinergic effects were measured. The extent of...
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