No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment.

doi:10.2217/epi-2015-0014

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Article

No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment.

Epigenomics - 1 May 2016

Bey Katharina, Wolfsgruber Steffen, Karaca Ilker, Wagner Holger, Lardenoije Roy, Becker Julian, Milz Esther, Kornhuber Johannes, Peters Oliver, Frölich Lutz, Hüll Michael, Rüther Eckart, Wiltfang Jens, Riedel-Heller Steffi, Scherer Martin, Jessen Frank, Maier Wolfgang, van den Hove Daniel L, Rutten Bart Pf, Wagner Michael, Ramirez Alfredo

Abstract excerpt

Alterations in DNA methylation have been associated with cognitive decline and Alzheimer's disease. A recent study of mild cognitive impairment (MCI) reported a significant association between annual decline in cognitive function and the rs11887120 SNP located in DNMT3A, a gene implicated in DNA methylation. Here, we aimed to replicate this finding in two independent MCI cohorts (n = 1024); however, no...

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PMID: 27092400
DOI: 10.2217/epi-2015-0014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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