DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts.

doi:10.2217/epi.15.22

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DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts.

Epigenomics - 1 Jan 2015

Chouliaras Leonidas, Kenis Gunter, Visser Pieter Jelle, Scheltens Philip, Tsolaki Magda, Jones Roy W, Kehoe Patrick G, Graff Caroline, Girtler Nicola G, Wallin Åsa K, Rikkert Marcel Olde, Spiru Luiza, Elias-Sonnenschein Lyzel S, Ramakers Inez H G B, Pishva Ehsan, van Os Jim, Steinbusch Harry W M, Verhey Frans R J, van den Hove Daniel L A, Rutten Bart P F

Abstract excerpt

Epigenetic dysregulation has been associated with cognitive decline and Alzheimer's disease. The present study investigated associations between common SNPs in genes regulating DNA methylation and age-related changes in cognitive decline in two independent prospective cohorts of patients suffering from mild cognitive impairment. An association between the rs1187120 SNP in DNMT3A and annual decline in cognitive...

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PMID: 26111027
DOI: 10.2217/epi.15.22

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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