Article
Genetics of Parkinson's Disease: From Causes to Treatment.
Cold Spring Harbor perspectives in medicine - 1 Jul 2025
Westenberger Ana, Brüggemann Norbert, Klein Christine
Abstract excerpt
The genetic architecture of Parkinson's disease (PD) comprises five autosomal dominantly inherited forms with a clinical picture overall resembling idiopathic disease (PARK-SNCA, PARK-LRRK2, PARK-VPS35, PARK-CHCHD2, and PARK-RAB32) and three recessive types (PARK-PRKN, PARK-PINK1, and PARK-PARK7), several monogenic forms causing atypical parkinsonism, as well as a plethora of known genetic risk factors, most...
Topics
- Humans
- Parkinson Disease
- Genetic Predisposition to Disease
- alpha-Synuclein
- Glucosylceramidase
- Mutation