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Article

Structural reverse genetics study of the PI5P4Kβ-nucleotide complexes reveals the presence of the GTP bioenergetic system in mammalian cells.

The FEBS journal - 1 Oct 2016

Takeuchi Koh, Senda Miki, Lo Yu-Hua, Kofuji Satoshi, Ikeda Yoshiki, Sasaki Atsuo T, Senda Toshiya

Abstract excerpt

Reverse genetic analysis can connect a gene and its protein counterpart to a biological function(s) by knockout or knockdown of the specific gene. However, when a protein has multiple biochemical activities, the conventional genetics strategy is incapable of distinguishing which biochemical activity of the protein is critical for the particular biological function(s). Here, we propose a structural reverse...

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Identifiers

PMID: 27090388
DOI: 10.1111/febs.13739
PMCID: PMC5053874

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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