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Article

Compartmentalization and regulation of GTP in control of cellular phenotypes.

Trends in molecular medicine - 1 Sept 2022

Wolff David W, Bianchi-Smiraglia Anna, Nikiforov Mikhail A

Abstract excerpt

Genetic or pharmacological inhibition of enzymes involved in GTP biosynthesis has substantial biological effects, underlining the need to better understand the function of GTP levels in regulation of cellular processes and the significance of targeting GTP biosynthesis enzymes for therapeutic intervention. Our current understanding of spatiotemporal regulation of GTP metabolism and its role in physiological and...

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Identifiers

PMID: 35718686
DOI: 10.1016/j.molmed.2022.05.012
PMCID: PMC9420775

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