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Article

A systematic approach for the genetic dissection of protein complexes in living cells.

Cell reports - 27 Jun 2013

Diss Guillaume, Dubé Alexandre K, Boutin Joël, Gagnon-Arsenault Isabelle, Landry Christian R

Abstract excerpt

Cells contain many important protein complexes involved in performing and regulating structural, metabolic, and signaling functions. One major challenge in cell biology is to elucidate the organization and mechanisms of robustness of these complexes in vivo. We developed a systematic approach to study structural dependencies within complexes in living cells by deleting subunits and measuring pairwise interactions...

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Identifiers

PMID: 23746448
DOI: 10.1016/j.celrep.2013.05.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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