Synaptopodin Is Dispensable for Normal Podocyte Homeostasis but Is Protective in the Context of Acute Podocyte Injury

Abstract excerpt

Significance Statement Synaptopodin is a podocyte actin-binding protein that regulates the cytoskeleton. Despite the cytoskeleton's critical role in podocytes and its alteration in nephrotic syndrome and FSGS, mutations in the synaptopodin gene SYNPO have not been reported in patients. Studies in Synpo mutant mice suggest that a truncated form of synaptopodin partially compensates for loss of the full-length...

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