Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.

doi:10.1038/nm.4082

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Article

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.

Nature medicine - 1 May 2016

Laklai Hanane, Miroshnikova Yekaterina A, Pickup Michael W, Collisson Eric A, Kim Grace E, Barrett Alex S, Hill Ryan C, Lakins Johnathon N, Schlaepfer David D, Mouw Janna K, LeBleu Valerie S, Roy Nilotpal, Novitskiy Sergey V, Johansen Julia S, Poli Valeria, Kalluri Raghu, Iacobuzio-Donahue Christine A, Wood Laura D, Hebrok Matthias, Hansen Kirk, Moses Harold L, Weaver Valerie M

Abstract excerpt

Fibrosis compromises pancreatic ductal carcinoma (PDAC) treatment and contributes to patient mortality, yet antistromal therapies are controversial. We found that human PDACs with impaired epithelial transforming growth factor-β (TGF-β) signaling have high epithelial STAT3 activity and develop stiff, matricellular-enriched fibrosis associated with high epithelial tension and shorter patient survival. In several...

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Source

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Identifiers

PMID: 27089513
DOI: 10.1038/nm.4082
PMCID: PMC4860133

Genes

STAT3
SMAD4
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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