Article
Update of the effect estimates for common variants associated with carotid intima media thickness within four independent samples: The Bonn IMT Family Study, the Heinz Nixdorf Recall Study, the SAPHIR Study and the Bruneck Study.
Atherosclerosis - 1 Jun 2016
Geisel Marie H, Coassin Stefan, Heßler Nicole, Bauer Marcus, Eisele Lewin, Erbel Raimund, Haun Margot, Hennig Frauke, Moskau-Hartmann Susanna, Hoffmann Barbara, Jöckel Karl-Heinz, Kedenko Lyudmyla, Kiechl Stefan, Kollerits Barbara, Mahabadi Amir-Abbas, Moebus Susanne, Nürnberg Gudrun, Nürnberg Peter, Paulweber Bernhard, Vens Maren, Willeit Johann, Willeit Karin, Klockgether Thomas, Ziegler Andreas, Scherag André, Kronenberg Florian
Abstract excerpt
Carotid intima media thickness (cIMT) is a marker for subclinical atherosclerosis. The most recent genome-wide association meta-analysis (GWAMA) from the CHARGE consortium identified four genomic regions showing either significant (ZHX2, APOC1, PINX1) or suggestive evidence (SLC17A4) for an association. Here we assess these four cIMT loci in a pooled analysis of four independent studies including 5446 individuals...
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