Article
Discovery of a potential lead compound for treating leprosy with dapsone resistance mutation in M. leprae folP1.
Molecular bioSystems - 21 Jun 2016
Nisha J, Ramanathan K, Nawaz Khan F, Dhanasekaran D, Shanthi V
Abstract excerpt
Dapsone resistance is a serious impediment to the implementation of the present leprosy control strategies. In the recent past, many studies have been undertaken to address the antibiotic activity and binding pattern of dapsone against both native and mutant (Pro55Leu) folP1. Yet, there is no well-developed structural basis for understanding drug action and there is dire need for new antibacterial therapies. In...
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