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Article

SLC22A1/OCT1 Genotype Affects O-desmethyltramadol Exposure in Newborn Infants.

Therapeutic drug monitoring - 1 Aug 2016

Matic Maja, de Wildt Saskia N, Elens Laure, de Hoon Jan N, Annaert Pieter, Tibboel Dick, van Schaik Ron H N, Allegaert Karel

Abstract excerpt

BACKGROUND: This study determined whether the SLC22A1 [encoding the organic cation transporter 1 (OCT1)] genotype could explain, in addition to the postmenstrual age (referring to gestational plus postnatal age) and CYP2D6 genotype, the tramadol (M) pharmacokinetic variability in early infancy. METHODS: Fifty infants, median postmenstrual age 39.5 (interquartile range: 36.8-41.3) weeks, received an i.v. M loading...

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Share to Analgesics, Opioid
Share to Cytochrome P-450 CYP2D6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Octamer Transcription Factor-1

Share to Organic Cation Transporter 1

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 27082504
DOI: 10.1097/FTD.0000000000000307

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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