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Article

Tramadol and o-desmethyl tramadol clearance maturation and disposition in humans: a pooled pharmacokinetic study.

Clinical pharmacokinetics - 1 Feb 2015

Allegaert Karel, Holford Nick, Anderson Brian J, Holford Sam, Stuber Frank, Rochette Alain, Trocóniz Iñaki F, Beier Horst, de Hoon Jan N, Pedersen Rasmus S, Stamer Ulrike

Abstract excerpt

BACKGROUND AND OBJECTIVES: We aimed to study the impact of size, maturation and cytochrome P450 2D6 (CYP2D6) genotype activity score as predictors of intravenous tramadol disposition. METHODS: Tramadol and O-desmethyl tramadol (M1) observations in 295 human subjects (postmenstrual age 25 weeks to 84.8 years, weight 0.5-186 kg) were pooled. A population pharmacokinetic analysis was performed using a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25258277
DOI: 10.1007/s40262-014-0191-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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