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Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy.

eLife - 10 Nov 2020

Shaw Joseph, Gosain Rajendra, Kalita Monoj Mon, Foster Toshana L, Kankanala Jayakanth, Mahato D Ram, Abas Sonia, King Barnabas J, Scott Claire, Brown Emma, Bentham Matthew J, Wetherill Laura, Bloy Abigail, Samson Adel, Harris Mark, Mankouri Jamel, Rowlands David J, Macdonald Andrew, Tarr Alexander W, Fischer Wolfgang B, Foster Richard, Griffin Stephen

Abstract excerpt

Since the 1960s, a single class of agent has been licensed targeting virus-encoded ion channels, or 'viroporins', contrasting the success of channel blocking drugs in other areas of medicine. Although resistance arose to these prototypic adamantane inhibitors of the influenza A virus (IAV) M2 proton channel, a growing number of clinically and economically important viruses are now recognised to encode essential...

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Antiviral Agents
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High-Throughput Screening Assays

Protein Conformation

Structure-Activity Relationship

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PMID: 33169665
DOI: 10.7554/eLife.52555
PMCID: PMC7714397

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Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy.PMID 33169665Read ↗

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