Article

The Structure of the Picornaviral 2C:RNA holoenzyme: Molecular Basis of RNA binding and specificity by a AAA+ protein

2026-06-10

Abstract excerpt

Picornaviruses are one of the leading agents of animal and human infectious disease with at least 8 billion infections a year and cause a range of symptoms including respiratory failure and acute flaccid myelitis 1 . The most conserved nonstructural protein in picornaviruses is 2C 2 , a member of the AAA+ family of ATPases that binds RNA, and a broad spectrum antiviral target 3–5 . Despite its crucial role in t...

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Literature Corpus work: 4414993e-08df-5e15-b4a9-543a118de2e8
DOI: 10.64898/2026.06.07.730651

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