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Article

Imbalanced Rab3D versus Rab27 increases cathepsin S secretion from lacrimal acini in a mouse model of Sjögren's Syndrome.

American journal of physiology. Cell physiology - 1 Jun 2016

Meng Zhen, Edman Maria C, Hsueh Pang-Yu, Chen Chiao-Yu, Klinngam Wannita, Tolmachova Tanya, Okamoto Curtis T, Hamm-Alvarez Sarah F

Abstract excerpt

The mechanism responsible for the altered spectrum of tear proteins secreted by lacrimal gland acinar cells (LGAC) in patients with Sjögren's Syndrome (SS) remains unknown. We have previously identified increased cathepsin S (CTSS) activity as a unique characteristic of tears of patients with SS. Here, we investigated the role of Rab3D, Rab27a, and Rab27b proteins in the enhanced release of CTSS from LGAC....

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Source

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Identifiers

PMID: 27076615
DOI: 10.1152/ajpcell.00275.2015
PMCID: PMC4935202

Genes

CTSS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Imbalanced Rab3D versus Rab27 increases cathepsin S secretion from lacrimal acini in a mouse model of Sjögren's Syndrome.PMID 27076615Read ↗

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