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Article

Lysosome-associated membrane protein 3 misexpression in salivary glands induces a Sjögren's syndrome-like phenotype in mice.

Annals of the rheumatic diseases - 1 Aug 2021

Nakamura Hiroyuki, Tanaka Tsutomu, Pranzatelli Thomas, Ji Youngmi, Yin Hongen, Perez Paola, Afione Sandra A, Jang Shyh-Ing, Goldsmith Corrine, Zheng Chang Yu, Swaim William D, Warner Blake M, Hirata Noriyuki, Noguchi Masayuki, Atsumi Tatsuya, Chiorini John A

Abstract excerpt

OBJECTIVES: Sjögren's syndrome (SS) is an autoimmune sialadenitis with unknown aetiology. Although extensive research implicated an abnormal immune response associated with lymphocytes, an initiating event mediated by salivary gland epithelial cell (SGEC) abnormalities causing activation is poorly characterised. Transcriptome studies have suggested alternations in lysosomal function are associated with SS, but a...

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Identifiers

PMID: 33658234
DOI: 10.1136/annrheumdis-2020-219649
PMCID: PMC8292598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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