Sjogrens syndrome—the non-apoptotic model of glandular hypofunction

Abstract excerpt

The ‘classical’ model to explain glandular hypofunction in Sjögrens syndrome (SS) is tissue loss secondary to immune attack mediated by a combination of apoptosis and cytotoxic cell death (reviewed recently by Ramos-Casals and Font [1]). In this model, the process of glandular destruction is made self-sustaining by the continued production of novel ‘self’ antigens, secondary to apoptotic bleb formation or...

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