Article
A Rab11a-enriched subapical membrane compartment regulates a cytoskeleton-dependent transcytotic pathway in secretory epithelial cells of the lacrimal gland.
Journal of cell science - 15 Oct 2011
Xu Shi, Edman Maria, Kothawala Mubashera S, Sun Guoyong, Chiang Lilian, Mircheff Austin, Zhu Lixin, Okamoto Curtis, Hamm-Alvarez Sarah
Abstract excerpt
Despite observations that the lacrimal gland has been identified as the principal source of dimeric immunoglobulin A (dIgA) in tears, the mechanism used by lacrimal gland acinar cells (LGACs) to transcytose dIgA produced by interstitial plasma cells is not well-characterized. This study identifies a transcytotic pathway in LGACs regulated by Rab11a for polymeric immunoglobulin receptor (pIgR) and dIgA....
Topics
- Acinar Cells
- Animals
- Cell Compartmentation
- Cell Membrane
- Cytoskeleton
- Female
- Gene Expression Regulation
- Immunoglobulin A
- Lacrimal Apparatus
- Mutation