Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interleukin-6 Deficiency Does Not Affect Motor Neuron Disease Caused by Superoxide Dismutase 1 Mutation.

PloS one - 1 Jan 2016

Han Yongmei, Ripley Barry, Serada Satoshi, Naka Tetsuji, Fujimoto Minoru

Abstract excerpt

BACKGROUND & AIM: Amyotrophic Lateral Sclerosis (ALS) is an adult-onset, progressive, motor neuron degenerative disease. Recent evidence indicates that inflammation is associated with many neurodegenerative diseases including ALS. Previously, abnormal levels of inflammatory cytokines including IL-1β, IL-6 and TNF-α were described in ALS patients and/or in mouse ALS models. In addition, one study showed that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Interleukin-1beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-6

Share to Motor Neuron Disease

Share to Motor Neurons

Share to Spinal Cord

Share to Superoxide Dismutase

Share to Superoxide Dismutase-1

Source

Open in PubMed Open full text

Identifiers

PMID: 27070121
DOI: 10.1371/journal.pone.0153399
PMCID: PMC4829212

Genes

SOD1
TNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interleukin-6 Deficiency Does Not Affect Motor Neuron Disease Caused by Superoxide Dismutase 1 Mutation.PMID 27070121Read ↗

IL-6 Protein Expression is Increased in Fast Glycolytic Muscle Fibers Over Time in the SOD1G93A Mouse model.Semantic proximity Read ↗

Absence of tumor necrosis factor-alpha does not affect motor neuron disease caused by superoxide dismutase 1 mutations.Semantic proximity Read ↗

Astroglial inhibition of NF-κB does not ameliorate disease onset and progression in a mouse model for amyotrophic lateral sclerosis (ALS).Semantic proximity Read ↗

Interleukin-6, a Major Cytokine in the Central Nervous SystemSemantic proximity Read ↗

Absence of receptor for advanced glycation end product (RAGE) reduces inflammation and extends survival in the hSOD1 <sup>G93A</sup> mouse model of amyotrophic lateral sclerosisSemantic proximity Read ↗

Very Early Involvement of Innate Immunity in Peripheral Nerve Degeneration in SOD1-G93A Mice.Semantic proximity Read ↗

IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients.Semantic proximity Read ↗

Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis.Semantic proximity Read ↗

Soluble RAGE Treatment Delays Progression of Amyotrophic Lateral Sclerosis in SOD1 MiceSemantic proximity Read ↗

Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALSSemantic proximity Read ↗

Increased Circulating Levels of Interleukin‐6 Induce Perturbation in Redox‐Regulated Signaling Cascades in Muscle of Dystrophic MiceSemantic proximity Read ↗

Increased post-traumatic survival of neurons in IL-6-knockout mice on a background of EAE susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.