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Article

Absence of tumor necrosis factor-alpha does not affect motor neuron disease caused by superoxide dismutase 1 mutations.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Nov 2006

Gowing Geneviève, Dequen Florence, Soucy Geneviève, Julien Jean-Pierre

Abstract excerpt

An increase in the expression of the proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha) has been observed in patients with amyotrophic lateral sclerosis (ALS) and in the mice models of the disease. TNF-alpha is a potent activator of macrophages and microglia and, under certain condi...

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Source

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Identifiers

PMID: 17079668
DOI: 10.1523/JNEUROSCI.0602-06.2006
PMCID: PMC6674545

Genes

TNF
SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17079668-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Absence of tumor necrosis factor-alpha does not affect motor neuron disease caused by superoxide dismutase 1 mutations.PMID 17079668Read ↗

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