Article
FCGR2A polymorphism is correlated with clinical outcome after immunotherapy of neuroblastoma with anti-GD2 antibody and granulocyte macrophage colony-stimulating factor.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Jun 2006
Cheung Nai-Kong V, Sowers Rebecca, Vickers Andrew J, Cheung Irene Y, Kushner Brian H, Gorlick Richard
Abstract excerpt
PURPOSE: Anti-GD2 murine IgG3 antibody 3F8 kills neuroblastoma cells by antibody-dependent cell-mediated cytotoxicity (ADCC). Granulocyte macrophage colony-stimulating factor (GM-CSF) enhances phagocyte-mediated ADCC. The differential affinity of the human FCGR polymorphic alleles for 3F8 may influence the effectiveness of antibody immunotherapy. PATIENTS AND METHODS: The entire cohort of high risk neuroblastoma...
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