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Article

Glycolytic Enzymes Localize to Synapses under Energy Stress to Support Synaptic Function.

Neuron - 20 Apr 2016

Jang SoRi, Nelson Jessica C, Bend Eric G, Rodríguez-Laureano Lucelenie, Tueros Felipe G, Cartagenova Luis, Underwood Katherine, Jorgensen Erik M, Colón-Ramos Daniel A

Abstract excerpt

Changes in neuronal activity create local and transient changes in energy demands at synapses. Here we discover a metabolic compartment that forms in vivo near synapses to meet local energy demands and support synaptic function in Caenorhabditis elegans neurons. Under conditions of energy stress, glycolytic enzymes redistribute from a diffuse localization in the cytoplasm to a punctate localization adjacent to...

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Identifiers

PMID: 27068791
DOI: 10.1016/j.neuron.2016.03.011
PMCID: PMC4840048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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