Article
A tissue-specific approach to the analysis of metabolic changes in Caenorhabditis elegans.
PloS one - 1 Jan 2011
Hench Jürgen, Bratić Hench Ivana, Pujol Claire, Ipsen Sabine, Brodesser Susanne, Mourier Arnaud, Tolnay Markus, Frank Stephan, Trifunović Aleksandra
Abstract excerpt
The majority of metabolic principles are evolutionarily conserved from nematodes to humans. Caenorhabditis elegans has widely accelerated the discovery of new genes important to maintain organismic metabolic homeostasis. Various methods exist to assess the metabolic state in worms, yet they often require large animal numbers and tend to be performed as bulk analyses of whole worm homogenates, thereby largely...
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