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Article

Matrix metalloproteinase (MMP)-19-deficient fibroblasts display a profibrotic phenotype

10 Jan 2015

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a progressive and usually lethal interstitial lung disease of unknown etiology characterized by aberrant activation of epithelial cells that induce the migration, proliferation and activation of fibroblasts. The resulting distinctive fibroblastic/myofibroblastic foci are responsible for the excessive extracellular matrix (ECM) production and abnormal lung remodeling. We have...

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PMID: 25575513
DOI: 10.1152/ajplung.00043.2014

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