Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interaction of NCOR/SMRT Repressor Complexes with Papillomavirus E8^E2C Proteins Inhibits Viral Replication

11 Apr 2016

Abstract excerpt

Infections with high-risk human papillomaviruses (HR-HPV) such as HPV16 and 31 can lead to ano-genital and oropharyngeal cancers and HPV types from the beta genus have been implicated in the development of non-melanoma skin cancer. HPV replicate as nuclear extrachromosomal plasmids at low copy numbers in undifferentiated cells. HPV16 and 31 mutants have indicated that these viruses express an E8^E2C protein which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cervical Cancer and HPV Research
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27064408
DOI: 10.1371/journal.ppat.1005556

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction of NCOR/SMRT Repressor Complexes with Papillomavirus E8^E2C Proteins Inhibits Viral ReplicationPMID 27064408Read ↗

NCoR1 Mediates Papillomavirus E8^E2C Transcriptional RepressionSemantic proximity Read ↗

The Viral E8^E2C Repressor Limits Productive Replication of Human Papillomavirus 16Semantic proximity Read ↗

Human papillomavirus 16 E2 regulates keratinocyte gene expression relevant to cancer and the viral life cycleSemantic proximity Read ↗

Human papillomavirus 16 E6 and E7 synergistically repress innate immune gene transcriptionSemantic proximity Read ↗

The E8 Domain Confers a Novel Long-Distance Transcriptional Repression Activity on the E8^E2C Protein of High-Risk Human Papillomavirus Type 31Semantic proximity Read ↗

Growth Inhibition of HeLa Cells Is a Conserved Feature of High-Risk Human Papillomavirus E8^E2C Proteins and Can Also Be Achieved by an Artificial Repressor ProteinSemantic proximity Read ↗

The papillomavirus E8-E2C protein represses DNA replication from extrachromosomal origins.Semantic proximity Read ↗

Association of an intact E2 gene with higher HPV viral load, higher viral oncogene expression, and improved clinical outcome in HPV16 positive head and neck squamous cell carcinomaSemantic proximity Read ↗

Post-Transcriptional Gene Regulation by HPV 16E6 and Its Host Protein PartnersSemantic proximity Read ↗

The HPV8 E6 protein targets the Hippo and Wnt signaling pathways as part of its arsenal to restrain keratinocyte differentiationSemantic proximity Read ↗

Evidence Supporting a Role for TopBP1 and Brd4 in the Initiation but Not Continuation of Human Papillomavirus 16 E1/E2-Mediated DNA ReplicationSemantic proximity Read ↗

Differentiation-Dependent Proximity Proteomics Identifies Novel Host Factors Linked to HPV16 E2 FunctionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.