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NCoR1 Mediates Papillomavirus E8^E2C Transcriptional Repression

25 Feb 2010

Abstract excerpt

The papillomavirus E2 open reading frame encodes the full-length E2 protein as well as an alternatively spliced product called E8;E2C. E8;E2C has been best studied for the high-risk human papillomaviruses, where it has been shown to regulate viral genome levels and, like the full-length E2 protein, to repress transcription from the viral promoter that directs the expression of the viral E6 and E7 oncogenes. The...

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PMID: 20181716
DOI: 10.1128/jvi.02390-09

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