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The Viral E8^E2C Repressor Limits Productive Replication of Human Papillomavirus 16

7 Nov 2013

Abstract excerpt

Productive replication of human papillomavirus type 16 (HPV16) occurs only in differentiated keratinocyte cells. In addition to the viral E2 activator protein, HPV16 and related HPV types express transcripts coding for an E8^E2C fusion protein, which limits genome replication in undifferentiated keratinocytes. To address E8^E2C's role in productive replication of HPV16, stable keratinocyte cell lines containing...

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PMID: 24198405
DOI: 10.1128/jvi.02296-13

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