Article
Association of polymorphisms in the MyD88, IRAK4 and TRAF6 genes and susceptibility to type 2 diabetes mellitus and diabetic nephropathy in a southern Han Chinese population.
Molecular and cellular endocrinology - 5 Jul 2016
Guo Congcong, Zhang Liju, Nie Lihong, Zhang Na, Xiao Di, Ye Xingguang, Ou Meiling, Liu Yang, Zhang Baohuan, Wang Man, Lin Hansheng, Yang Guang, Jing Chunxia
Abstract excerpt
Type 2 diabetes mellitus (T2DM) has been linked to a state of low-grade inflammation resulting from abnormalities in the innate immune pathway. MyD88 is an essential adaptor protein for TLR signaling, which is involved in activating NF-κB through IRAK4 and TRAF6. To investigate the effects of the MyD88, IRAK4 and TRAF6 polymorphisms in the susceptibility of T2DM and diabetic vascular complications, eight SNPs...
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