Article
The effects of TLR3, TRIF and TRAF3 SNPs and interactions with environmental factors on type 2 diabetes mellitus and vascular complications in a Han Chinese population.
Gene - 30 Aug 2017
Zhou Zixing, Zeng Chengli, Nie Lihong, Huang Shiqi, Guo Congcong, Xiao Di, Han Yajing, Ye Xiaohong, Ou Meiling, Huang Chuican, Ye Xingguang, Wen Zihao, Yang Guang, Jing Chunxia
Abstract excerpt
Toll-like receptor 3 (TLR3) is involved in type I interferon-β (IFN-β) via TIR-domain-containing adapter-inducing interferon-β (TRIF) and Tumor necrosis factor receptor-associated factor 3 (TRAF3), culminating in inflammation and immunity reactions. TLR3 is implicated in insulin resistance and type 2 diabetes mellitus (T2DM). Eight SNPs of these genes were detected in 552 T2DM patients and 552 matched healthy...
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