Intracellular evolution of mitochondrial DNA (mtDNA) and the tragedy of the cytoplasmic commons.

doi:10.1002/bies.201600003

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Article

Intracellular evolution of mitochondrial DNA (mtDNA) and the tragedy of the cytoplasmic commons.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Jun 2016

Haig David

Abstract excerpt

Mitochondria exist in large numbers per cell. Therefore, the strength of natural selection on individual mtDNAs for their contribution to cellular fitness is weak whereas the strength of selection in favor of mtDNAs that increase their own replication without regard for cellular functions is strong. This problem has been solved for most mitochondrial genes by their transfer to the nucleus but a few critical genes...

Topics

Aging
Animals
Apoptosis
Biological Evolution
DNA, Mitochondrial
Female
Humans
Mitochondria
Mitophagy
Mutation
Ovum

Source

Open in PubMed

Identifiers

PMID: 27062292
DOI: 10.1002/bies.201600003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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